奥格门丁与头孢拉定随机对照治疗细菌性感染  

Randomized controlled treatment of bacterial infections on augmentin compared with cephradine

作　　者：侯杰[1] 李家泰[1] 陈亦芳[1] 张朴[1] 尹非[1] 

机构地区：[1]北京医科大学临床药理研究所,北京100034

出　　处：《中国医院药学杂志》1993年第11期509-511,共3页Chinese Journal of Hospital Pharmacy

摘　　要：奥格门丁(Augmentin)是棒酸(Clavulanic acid)与羟氨苄青霉素(Amoxicillin)的复方制剂,内含羟氨苄青霉素1.0g,棒酸0.2g。本组所用奥格门丁静脉注射针剂为英国比切姆公司原粉,由华北制药厂生产提供。本组试验共治疗细菌性感染42例。其中16例试验药奥格门丁与对照药头孢拉定(Cephradine)16例进行随机对照临床试验,两组临床痊愈显效率分别为87.5%与81.3%,细菌消除率分别为83.3%与81.3%;奥格门丁共观察26例(开放10例,随机对照16例),临床痊愈显效率为88.5%,细菌消除率为85.7%,不良反应发生率15.38%。Augmentin(AUG)is a combination of clavulanic acid(CA)and amoxycillin(AMO).Test compounds for clinical trials were provided by Huabei Pharmaceutical Factory,using import raw materials from the Beecham Company.In the controlled clinical trial,32 patients were randomized to receive either AUG(16 patients)or cephradine(CPH,16 patients).The dosage and therapeutic duration were as follows:AUG 1.2g,CPH 1～2g,intravenously,3 to 4 times per day for 10 to 14 days.The curative rate plus excellence rate of AUG and CPH were 87.5% and 81.3% respectively.The bacterial clearance rate of the two groups was 83.3% and 81.3% respectively.The total number of patients treated by AUG was 26 cases(16 patients in controlled study and 10 patients in open trial).The curative rate plus excellence rate,bacterial clearance rate and ADR rate of 26 cases treated with AUG were 88.5%,85.7% and 15.38%.

关 键 词：奥格门丁 头孢拉定 细菌感染 

分 类 号：R969.4[医药卫生—药理学]