肾脏的自由基代谢与运动性蛋白尿关系的实验研究  

The Relationship between the Free Radical in kidney and postexercise Proteinuria

作　　者：商品 许豪文[2] 

机构地区：[1]上海卢湾体育科学研究所,200020 [2]华东师范大学体育系

出　　处：《中国运动医学杂志》1993年第4期215-218,共4页Chinese Journal of Sports Medicine

摘　　要：本文依据运动性肾缺血再灌的理论,探讨了运动性蛋白尿的发生机制。利用ESR技术报导了运动后肾脏出现的新的自由基信号,同时观察了运动前后肾线粒体膜和肾组织超微结构的改变,认为运动后引起的尿TP、ALb、β_2-MG排泄率增加和上述反应密切相关。提示:运动后OFR产生与肾脏脂质过氧化反应可能是运动性蛋白尿形成的重要因素之一。In this paper, the mechanism of postexercise proteinuria was studied bas-ed on the theory of ischemic reperfusion.The parameters observed at rest(Grp 1), 30 minutes after exercise ( Grp 2 ) and allopurinol injected after ex-ercise ( Grp 3 ) included renal supermicrostructure, lipid fluidity ( LFD), lipidperoxide ( LPO ) and superoxide dismutase ( SOD ) of renal mitochondrial mem-brane: the exertion rate of urinary total protein(TP), albumin ( ALB ) and β 2-macroglobulin ( β_2-MG).The results were as follows:1. A sharp major free ra-dical signal in Electron Spin Resonance(ESR)was found in Grp 2; 2. Comparedwith Grp 1, the SOD and LFD decreased ( p<0.01 ) following apparent increaseof LPO level in Grp 2 (p<0.01); 3. Compared with Grp l and 3, urinaryexertion of TP, ALB and β 2-MG increased in Grp 2 (p<0.01); 4. The renalmorphological changes were slight. It was concluded that the production ofrenal free radical might be caused by renal ischemic reperfusion.The decreaseof the renal blood flow during exercise and the reperfusion after exercise mightbe the important factors of the postexercise proteinuria.

关 键 词：蛋白尿 缺血再灌注 自由基 

分 类 号：G804.21[文化科学—运动人体科学]