黄芪多糖增强人外周血单个核细胞产生肿瘤坏死因子的研究  

Effect of Astragalan on Secretion of Tumor Necrosis Factors in Human Peripheral Blood Mononuclear Cells

作　　者：赵克胜[1] 丁丽轩[1] 孔海燕[1] 田淑媛[1] 金伯泉 刘雪松 

机构地区：[1]陕西省人民医院,西安710068 [2]第四军医大学

出　　处：《中国中西医结合杂志》1993年第5期263-265,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：常规提取的黄芪多糖经液相色谱进一步分离后,发现其中分子量为20 000～25 000的组分,对正常人及肿瘤患者外周血单个核细胞(PBMC)在体外分泌肿瘤坏死因子(TNF)具有明显地促进作用。进一步将PBMC分离成粘附和非粘附细胞后发现,黄芪多糖的这一组分对二者分别产生TNF-α和TNF-β均有增强作用,表明对黄芪多糖的进一步研究将有利于其在肿瘤治疗中的应用。The extracts of Astraglus membranaceus have been further isolated by liquid chromatography.One of the fractions (Astragalan, M. W. 20,000-25,000) could enhance the secretion of tumor necrosisfactor (TNF) from human peripheral blood mononuclear cells (PBMC) in vitro. After isolation ofadherent and nonadherent mononuclear cells from PBMC, Astragalan increased the secretion ofTNF-α and TNF-β respectively. These results suggest further study of Astragalan would promotethe application of Astragalan in cancer immunotherapy.

关 键 词：黄芪 多糖 肿瘤坏死因子 PBMC 细胞 

分 类 号：R285.5[医药卫生—中药学]