补中益气汤治疗慢性乙型肝炎的临床与实验研究  

Clinical and Experimental Observations of Buzhong Yiqi Decoction in Treating Chronic Hepatitis B

作　　者：杜发斌 王汝俊[2] 邵庭荫[2] 张永锋[2] 傅定中[2] 王建华[2] 

机构地区：[1]湖北省恩施医学专科学校中医系,湖北445000 [2]广州中医学院脾胃研究所

出　　处：《中国中西医结合杂志》1993年第6期333-335,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：通过对补中益气汤及西药治疗慢性乙型肝炎临床疗效的对比研究,发现补中益气汤能较快改善慢性乙型肝炎的临床症状及体征,改善肝功能,促使乙型肝炎病毒血清学标志好转(HBsAg、HBeAg转阴或滴度下降,抗-HBe或抗-HBs转为阳性),与西药治疗对照组比较有显著性差异(P<0.05)。动物实验观察了补中益气汤对小鼠肝组织DNA、RNA、蛋白质合成的影响,结果表明,补中益气汤对三者的合成均有明显的促进作用。其抗肝炎的作用机制可能与该方增强肝脏蛋白质的合成,促进肝组织的修复,改善机体整体的抗病机能有关。A clinical observation of Buzhong Yiqi decoction (BZYQD) and Western medicine was used ona matched control in treating chronic hepatitis B. The result showed that BZYQD was significantlybetter than the Western medicine in improving clinical symptoms and signs, the liver function andserological test of hepatitis B antigen-antibody system (HBAg-Ab system), P<0.05. In order toexplore the therapeutical mechanism of BZYQD, the study of the effects of which on synthesis ofhepatic DNA, RNA and protein in mice were performed too. The results showed that BZYQD hadmarked promotive effects on the synthesis of hepatic DNA, RNA and protein. It was considered that the mechanism of antihepatitis effects might related to the enhancing protein synthesis in liver,promoting the repairs of the damaged liver tissue and improving the defense function of organismas a whole.

关 键 词：补中益气汤 乙型肝炎 DNA 汤剂 

分 类 号：R512.620.5[医药卫生—内科学]