重症充血性心力衰竭几种治法的对比分析  

Comparative Analysis of Several Treatment Methods for Severe Congestive Heart Failure

作　　者：楼正家[1] 祝光礼[1] 孙西璐[1] 陈智新[1] 

机构地区：[1]杭州市中医院,杭州310006

出　　处：《中国中西医结合杂志》1993年第8期458-460,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：单用西药和中西药结合治疗观察127例重症充血性心力衰竭(CHF),西药3组分别用地高辛加双氢克尿噻或开搏通加心痛定或多巴酚丁胺。中西药结合3组分别在上述西药基础上用济生肾气丸加减。通过对各组的治疗结果分析,笔者认为:(1)CHF的治疗必须做到个体化用药,才能取得最佳疗效。(2)中西药结合治疗能明显提高疗效,减少毒副作用,降低病死率。(3)济生肾气丸能明显改善心室舒张功能,其机理可能是使下降的β_1受体密度增高。Western medicines (WM) and the combining WM-TCM were used to treat congestive heart failure (CHF). The three groups of WM were: Digoxin with dihydro-chlorothiazide, captopril with nifedipium, and dobutamine. The three groups of combining WM-TCM were: the above-mentioned three groups of WM with Jisen Shenqi Pill (JSSQ) respectively. The result observed: Total effective rate was 82%, marked effective rate was 43%, the rates of the WM groups were 77% and 36% respectively, and the groups of combining WM-TCM were 88% and 53%. Total mortality was 8.66% (the WM groups was 11.76%, the groups of combining WM-TCM 5%). Cardio-function indexes observed in the groups of combining WM-TCM were obviously improved, including HR, SV, CI, EF, FS and A/E (P<0.01). HR, CI and SV in the groups of WM were also significantly improved (P<0.05) except for EF, FS and A/E (P>0.05). Conclusions: (1) The treatment of CHF should depend on various conditions and different symptoms in selecting medicines, so that individual treatment could reach the optimal effects. (2) The treatment method of combining WM-TCM could significantly promote effective rate, reduce toxic and side-effects and lower the rate of mortality. (3) JSSQ could obviously improve the function of ventricular diastole and its mechanism might be that the reduced density of β-receptor was increased.

关 键 词：充血性 心力衰竭 中西医结合 

分 类 号：R541.610.5[医药卫生—心血管疾病]