荆芥炭提取物止血活性部位的研究  

Research on Hemostatic Constituents in Carbonized Schizonepeta tenu ifolia Brig.

作　　者：丁安伟[1] 孔令东[1] 吴皓[1] 王苏玲[1] 龙全江 姚征 陈江 

机构地区：[1]南京中医学院,210029

出　　处：《中国中药杂志》1993年第9期535-538,共4页China Journal of Chinese Materia Medica

摘　　要：研究结果表明,荆芥炭的脂溶性提取物StE具有明显的止血作用,在一定剂量范围内,其对数剂量与小鼠的凝血和出血时间的倒数呈显著性线性相关。StE给小鼠ip后0.5h,家兔po后1h即可见到明显的止血作用,其作用维持时间分别为6h及12h。StE的LD_(50)(po)为2.652±0.286g/kg,LD_(50)(ip)为1.945±0.207g/kg。It has been shown that the fatsoluble extract SeE from carbonized Schizonepeta tenuifolia has an obvious hemostatic action. In a given range of dose there is a significant linear correlation between the logarithms of its doses and the reciprocal of the bleeding and coagulating times in mice, Obvious hemostatic action was observed after mice had been administered in ip and po respectively for 0.5h and 1h. The hemostatic time of the former was 6h and the latter 12h. The LD_(60) of StE in po was 2.652±0.286g/kg, while in ip 1.945±0.207g/kg.

关 键 词：荆芥 荆芥炭 止血 量效关系 

分 类 号：R282.710.5[医药卫生—中药学]