益精注射液对心衰猫心功能及血流动力学影响的实验研究  

Experimental Study on the Influence of Injection for Replenishing Vital Essence on the Cardiac Function and Hemodynamics of Cats with Heart Failure

作　　者：伊永禄 王强[1] 赵英强[1] 张超[1] 贾颜焘 张庆元[2] 赵振海[2] 李萌[3] 

机构地区：[1]天津中医学院附一院,天津300193 [2]国家医药管理局天津药物研究院,天津300000 [3]天津医药科学研究所,天津300000

出　　处：《中国中医急症》1993年第1期36-38,共3页Journal of Emergency in Traditional Chinese Medicine

摘　　要：益精注射液(YJ)是立足于中医基础理论.结合笔者多年临床经验.研制出的中药复方静脉制剂,具有补肾益精气之功效。本实验以静脉注射2％戊巴比妥钠造成猫心衰模型,然后分次静注益精注射液(0.5g/kg、1g/kg),观察其对心衰猫心功能及血流动力学的影响,并与生脉注射液(SM)作了对比观察。实验结果表明:静注YJ后,可增加心衰猫的LVSP(左心室压力峰值)、±dp/dt max(左心室压力上升、下降最大速率);降低TPR(总外周阻力),从而明显增加心衰猫的CO(心输出量)、LVW(左室作功)、CI(心脏指数)、SV(心搏量)。在LVW明显增加同时,心肌耗氧量(MVO_2)增加甚少。对左室舒张功能亦有改善作用,对心率(HR)、血压(BP)无明显影响。其表明YJ能增强心肌的收缩性,降低外周阻力。减轻心脏负荷,尤其是后负荷,提高心脏作功效率,进而明显增强心泵功能而有利于心力衰竭的治疗。YJ与SM的对比观察表明:在增强心泵功能方面YJ略强于SM,但无统计学意义。而在降低心肌耗氧量,提高心脏效率方面YJ优于SM(p<0.05)。YJ1g/kg在降低总外周阻力方面与SM组比较(p<0.05),有显著性差异。In this experimental study, the influence of injection for replenishing vital essence (YJ) on the cardiac function and hemodynamics of cats with heart failure was contrasted with that of pulse-activating injection (SM). The results showed the former injection (YJ) was superior to latter (SM) in reducing the oxygen consumption of myocardium and enhancing the cardiac function, and a significant differ- ence in the total peripheral resistance existed between the two injections.

关 键 词：益精注射液 心力衰竭 血流动力学 

分 类 号：R285.5[医药卫生—中药学]