^(54)锰在小鼠睾丸和脑分布及对氨基水扬酸钠驱锰实验的研究  

MANGANESE TRANSFER VIA BLOOD TO TESTES AND BRAINS IN MALE MICE AND ITS EXCRETION IMPELLED BY SODIUM PARA—AMINOSALICYLIC ACID

作　　者：吴卫平[1] 孙瑜[1] 蒋学之[1] 王簃兰[1] 丁训诚 王中兴 

机构地区：[1]上海医科大学劳动卫生学教研室,200032 [2]上海市计划生育研究所

出　　处：《中华劳动卫生职业病杂志》1993年第3期143-146,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：单次给雄鼠腹腔注射0.25μCi/g体重的M_nCl_2,注射后锰可在睾丸、脑和其它器官中测出,表明锰是能够通过血睾屏障和血脑屏障产生蓄积和滞留。锰对小鼠下丘脑、垂体-睾丸轴的毒作用是由于锰直接作用于下丘脑和睾丸组织所致,未见在垂体内沉积。资料证明,PAS-Na能与睾丸和脑组织中锰作用并有一定的排锰效果。Transfer of manganese from blood to testes and brains and other organs was demonstrated by giving a single ip injection ofMnCl_2(0.25μCi/g)to male mice.The results showed that the blood—testes barrier and blood—brain barrier were morepermeable to manganese and that manganese was more readily accumulated in the testes and branin.The toxic effects of Mn onhypothalamic—pituitary—testicular axis in male mice may result fom the direct action of manganese on hypothalamus andtestes tissues.No Mn deposit in pituitary was found.The data also indicated that the blood—testes barrier blood brain barrierwere more permeable to PAS—Na,and that manganese was effectively combined and excreted in the testes and brain.

关 键 词：锰54 血睾屏障 血脑屏障 PAS-Na 

分 类 号：R965.1[医药卫生—药理学]