尿中叶枯灵及其代谢物的分析及代谢研究  

STUDIES OF YEKULING AND ITS METABOLITES IN URINE OF RAT BY GC-MS

作　　者：王宇[1] 李正化[1] 高宁[2] 

机构地区：[1]华西医科大学药学院新药设计研究室,成都610041 [2]第三军医大学卫防系环卫教研室

出　　处：《中华劳动卫生职业病杂志》1993年第4期223-225,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金："七.五"国家重点科技攻关项目

摘　　要：采用气相色谱—质谱联用(GC—MS)对农药叶枯灵经口染毒大鼠尿内的主要代谢产物进行了分离、鉴定。鉴定代谢产物分别为丙酮酸缩肼叉—1、3—二噻茂烷(Ⅱ)和马尿酸(Ⅰ),通过对代谢产物的化学合成,进一步确证它们的结构。并对叶枯灵在体内代谢转化过程进行了探讨。After the oral administration of fungicide,Yekuling,to rat,the main metabolites in urine of rat were isolated and identified by GC—MS.They were considered as pyruvic acid 1,3—dithiolan—2—ylidenhydrazone(Ⅱ)andN—benzoylglycine(Ⅰ).They were further confirmed by means of indentfication of the synthetic compounds.The metabolic pathway of Yekuling was dis- cussed.

关 键 词：尿 叶枯灵 代谢产物 

分 类 号：R139.3[医药卫生—劳动卫生]