新生儿TSH筛查在碘缺乏病监测中的应用  

NEONATAL TSH SCREENING IN THE MONITORING OF IODINE DEFICIENCY DISORDERS

作　　者：吴艺捷[1] 时鍾孚 张家秀[1] 于士光 王德珍[2] 王鸿涓 刘素华[4] 吴慎兴 杨一平[6] 蔡彰荃 周蓉 华菱芳 顾祖德 杨大全 

机构地区：[1]贵阳医学院附属医院内分泌科 [2]贵阳医学院附属医院妇产科,550001 [3]贵阳市妇幼保健院 [4]贵阳市第一人民医院 [5]贵阳市第二人民医院 [6]贵阳市第四人民医院 [7]都匀市妇幼保健院 [8]凯里市妇幼保健院 [9]黔东南州人民医院 [10]凯里418医院 [11]贵州省地方病防治办公室

出　　处：《中华内分泌代谢杂志》1993年第4期216-218,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：采用灵敏的免疫放射法筛查了9 251例新生儿滤纸血斑TSH水平,以监测贵州省的碘缺乏病。结果在贵阳、都匀和凯里三地区分别有39.22％、36.04％和38.80％的新生儿TSH水平升高(≥5mIU/L),但绝大多数为轻度升高(5～19.9％mlU/L。)。对TSH≥25mlU/L者追踪发现其可在2～30周中恢复正常(<5mlU/L)。新生儿暂时性高TSH血症者增多的状况,表明该地区仍有轻度碘缺乏存在。新生儿TSH筛查是监测碘缺乏病的更敏感指标。The blood-spotted filter paper TSH levels in 9 251 neonates were screened by means of a sensitive immunoradiometric assay (IRMA) for monitoring the iodine deficiency disorders (IDD) in Guizhou province. The results showed that 39. 22% .36. 04% and 38. 80% of neonates had TSH values ≥5 mIU/L in Guiyang, Duyun and Kaili areas repectively. But ,in the most of the neonates, their TSH levels showed only a mild increase (5. 0-19. 9 mlU/L). At follow-up examination,the neonates with TSH>25 mIU/L gradually had normal values (<5 mIU/L) in 2-30 weeks. Our results indicate that the presence of the transient neonatal hyperthy-rotropinemia suggests an iodine deficiency in some people of the studied areas. Neonatal TSH screening may be a more sensitive index for monitoring IDD.

关 键 词：新生儿 碘缺乏病 促甲状腺素 

分 类 号：R722.190.3[医药卫生—儿科]