上海地区汉族群体的HLA-DP基因分型  

THE HLA-DPA_1 AND-DPB_1 OLIGONUCLEOTIDE TYPES OF A Han POPULATION IN SHANGHAI AREA

作　　者：范丽安[1] 张锦锋 葛瑜 姚芳娟[1] 杨珏琴[1] 陈仁彪[1] M.Sirikong R.Vongrathna P.Longta D.Chandanayimgyong 

机构地区：[1]上海第二医科大学上海市免疫学研究所免疫遗传研究室,200025 [2]Department of transfortion medicine Siriraj Hospital Mahidol University Bangkok Thailand

出　　处：《中华医学遗传学杂志》1993年第3期131-134,共4页Chinese Journal of Medical Genetics

摘　　要：对上海地区48名汉族个体的基因组DNA用聚合酶链反应(PCR)扩增及对寡核苷酸探针(SSO)进行斑点杂交的方法研究了HLA-DPA1及DPB1基因分布情况。共检出DPB1等位基因9个,以0501等位基因占优势,检出率为64.6%,其次为0201及0401等位基因,检出率分别为27.1%和25.0%。结果表明,上海地区汉族群体的DPB1分布与白种人有明显不同,揭示不同人种有其自己的主要等位基因。HLA-DPA1 and-DPB1 allele frequencies in 48 unrelated Han normal individuals from Shanghai area were determined using PCR/SSO typing methods. DPA1'01 and ~*0201 were common alleles in this study. Nine DPB1 alleles were detected in this panel among them. HLA-DPB1~* 0501 allele was the most frequent allele in this panel possessed by 64.6% of individual, followed by HLA-DPB1~* 0201 (27.1%), 0401 (25.0%), 0202(14.6%), 0301 (10.4%), and 1701 only present with frequencies less than 10%. The results in this study are in broad agreement with the reports on other oriental populations and very different from Caucasian studies.

关 键 词：人白细胞抗原 DP 基因分型 多态性 

分 类 号：Q756[生物学—分子生物学]