青蒿琥酯对恶性疟原虫配子体感染性影响的观察  

INFLUENCE OF ARTESUNATE ON INFECTIVITY OF GAMETOCYTES OF PLASMODIUM FALCIPARUM

作　　者：陈沛泉[1] 李国桥[1] 简华香[1] 张跃荣[1] 符林春[1] 郑金影 范梨盛 阮氏杜 

机构地区：[1]广州中医学院热带医学研究所,广州510407 [2]越南胡志明市佐内医院 [3]越南同奈省春禄医院

出　　处：《中药新药与临床药理》1993年第3期40-42,共3页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：越南南方疟区15例携带恶性疟原虫配子体和无性体的患者分为A、B、C 3组,A组口服青蒿琥酯片5天总量600mg,B组口服青蒿琥酯片2天总量200mg,C组静脉注射青蒿琥酯5天总量360mg。给药前、后定时血检计算配子体密度,并取血离体感染大劣按蚊。配子体转阴时间,A组为15.4±5.0天,B组为20.6±4.8天,C组为20.3±4.0天。配子体失去感染性,A组D_7(给药后7天)2/5例、D_(14)5/5例;B组D_70/5例、D_(14)1/5例、D_(21)5/5例;C组D_70/5例、D_(14)2/4例、D_(21)3/3例。研究结果表明口服青蒿琥酯5天总量600mg对清除恶性疟原虫配子体血症及抑制配子体的感染性有明显影响。A study was carried out in south of Vietnam 15 Patients with Plasmodium falciparum gametocytes and asexual parasites were distributed into groups A, B and C. Artesunate was given orally at a total dose of 600 mg for 5 days in group A, 200 mg for 2 days in group B and intravenously at a total dose of 360 mg for 5 days in group C respectively. Gametocytes count was done before medication and daily after medication. Meanwhile, Anopheles dirus as a vector was employed to study the infectivity of gametocyte, The result showed that the mean gametocyte clearance time in three groups were respectively 15.4±5.0, 20.6±4.8 and 20.3±4.0 days. The mosquitoes were not infected from the blood in 2, 5 and 5 of 5 patients respectively on days 7, 14 and 21 in group A; 1 and 5 of 5 patients on day 14 and 21 in group B; 2 of 5 patients and 3 of 3 patients on days 14 and 21 in group C. It indicates that artesunate has remarkable effect on Plasmodium falciparum gametocytemia and its infectivity to mosquitoes.

关 键 词：青蒿琥酯片 疟疾 中医药疗法 疟原虫 配子体 

分 类 号：R285.5[医药卫生—中药学] R254.505[医药卫生—中医学]