川芎红花注射液对大鼠实验性脑栓塞后血液流变学、血小板聚集及血浆β—TG、cAMP含量的影响  

Effect of the Compound Injection of Rhizoma Chuanxiong and Flos Carthami (IRE) on the Blood Rheology, Platelet Agglutination, β-TG and cAMP Content of Plasma at the Cerebral Embolism in Rats

作　　者：李威[1] 李秋风[1] 邹明辉[1] 苗利军[1] 杨宁辉[1] 

机构地区：[1]河南省中医药研究院,河南450004

出　　处：《中医研究》1993年第4期17-21,共5页Traditional Chinese Medicinal Research

基　　金：国家中医药管理局青年中医科研基金

摘　　要：采用兔脑凝血活酶粉—高分子葡聚糖作为栓塞剂,造成大鼠脑栓塞模型。观察了川芎红花注射液对大鼠脑栓塞后不同时间的血液流变学、血小板聚集及血浆β—TG、cAMP含量的影响。结果表明:川芎红花注射液可降低大鼠脑栓塞后高、低切变率的全血粘度、红细胞变形能力、血球压积、血小板聚集率和血浆β—TG含量,提高血浆cAMP的含量。这些作用对治疗缺血性中风有重要意义。A new animal model of the cerebral embolism was established by injecting the solution of thromboplastin powder of rabbit brain and 10% dextran (TPRB-D) into the internal carotid artery in rats. Meanwhile, the effects of IRF on the blood rheology, platelet agglutination, β-TG and cAMP content of plasma were observed at 2th hour, 3th day and 9th day after operations. The results showed that the IRF could decrease the blood viscosity, packedcell volume, platelet agglutination and the β-TG content of plasma, prevent the reduction of erythrodegenerative and incerese the cAMP contect of plasma after the cerebral embolism in rats. The author considered that IRF could reduce the ischemic damage of cerebral embolism.

关 键 词：川芎红花针剂 脑栓塞 血液流变学 

分 类 号：R289.5[医药卫生—方剂学]