芪苓汤预防高剂量顺铂肾毒性的临床和实验研究  

Toxicity of Large Dose of Cisplatin on Kidney-Pre-vented by Decoction of Radix Astragali seu Hedysariand Poria

作　　者：程剑华[1] 张所乐 黄兆明[1] 龙浩[1] 竺家琍[1] 赵德慧 王晓[1] 朱力平[1] 刘伟新[1] 黎治平[1] 

机构地区：[1]江西省肿瘤医院,江西南昌市北京东路330029 [2]江西省老干部局

出　　处：《中医杂志》1993年第6期349-351,共3页Journal of Traditional Chinese Medicine

基　　金：江西省卫生厅资助的科研课题

摘　　要：临床观察到芪苓汤与高剂量顺铂合用时,BUN、Cr 无一例异常,生化检测指标有改善,且有明显利尿作用,水化对照组效果较差。实验证实,芪苓汤可预防和减轻顺铂对大鼠的肾损害。Clinical observation revealed that combined use of Decoction of Radix Astragali seu Hedysari and Poria withlarge dose of Cisplatin.none of the cases showed ab-normality in BUN,Cr.with improvement of biochemi-cal indices,there was also diuretic actions observed.Ahgdraton contrel group revealed worse result.The ex-periment proves that the Decoction is capable of pre-venting and ameliorating the harmful effect on kidneyinduced by Cisplatin in rats.

关 键 词：顺铂 毒性 肾疾病 芪苓汤 

分 类 号：R289.5[医药卫生—方剂学]