视黄酸对致癌剂苯芘环氧化及其与DNA结合的抑制作用  

Inhibition of Retinoic Acid on the Epoxy Reaction of Benzo(a)pyrene and Combination of Benzo(a)pyrene Epoxy Analogs with DNA

作　　者：阎熙丰[1] 刘际清[1] 许风芝[1] 刘素媛[2] 任永忠[2] 王殿鸿[2] 

机构地区：[1]沈阳军区总医院内五科 [2]中国医科大学生化教研室

出　　处：《肿瘤》1993年第2期86-89,共4页Tumor

基　　金：国家自然科学基金

摘　　要：本文采用氚标记苯芘及体外细胞培养方法,探讨维生素A的重要衍生物视黄酸的防癌机理,发现视黄酸对前致癌剂苯芘环氧化为终致癌剂及其与BALB/c系小鼠骨髓瘤细胞DNA的结合均有显著的抑制作用(P<0.01)。Anticarcinogenic mechanism of important analog retinoic acid of vitamin A was eaplored with ～3H-labelled benzo(a) pyrene and cell culture. It was discovered that theepoxy reaction of benzo(a) pyrene and the combination of ultimate carcinogen [～3H]-benzo(a)-pyrene epoxy analogs with DNA of myeloma cell from BALB/C mouse wereinhibited significantly by retinoic acid (P<0.01).

关 键 词：视黄酸 苯芘环氧化 抗癌作用 

分 类 号：R979.19[医药卫生—药品]