两种不同剂量Ge-132对二甲肼诱发大鼠大肠癌的作用  

Effect of Two Different Doses of Ge-132 on DMH--induced Colorectal Carcinogenesis in Rats

作　　者：宋卫生[1] 周殿元[2] 续正慧[2] 

机构地区：[1]第一军医大学珠江医院 [2]第一军医大学

出　　处：《肿瘤》1993年第2期75-78,共4页Tumor

摘　　要：在以二甲肼(DMH)诱发大鼠大肠癌的同时,给大鼠灌胃Ge-132 100mg/kg体重或300mg/kg体重共27周。Ge-132 100mg/kg体重组大鼠的平均癌灶数和平均癌灶体积,均显著少于对组照和Ge-132 300mg/kg体重组(P均<0.01)。Ge-132 300mg/kg体重组与对照组差异无显著意义(P>0.05)。肠镜检查显示,Ge-132 100mg/kg体重组致癌物所致结肠粘膜的炎症、萎缩和不典型增生明显轻于对照组(P<0.05),癌肿发生的潜伏期比对照组长3周。Ge-132 300mg/kg体重组与对组照差异无显著意义(P>0.05)。结果表明,Ge-132对化学诱癌的预防作用具有剂量依赖性。To find out the preventive effect of Ge-132 on colorectal carcinogenesis, rats weresubcutaneously injected with dimethylhydrazine (DMH) for 15 weeks and were givenGe-132 with two different doses (100 or 300mg/kg)by gastrogavage for 27 weeks.Results revealed that the mean cancer foci/rat and the mean cancer volume/rat werereduced by Ge-132 100mg/kg(P<0.01) and that the precancerous lesions resultedfrom carcinogen were reduced and the latent period of carcinogenesis was lengthenedby Ge-132 100mg/kg. There was no effect of cancer prevention with Ge-132 300mg/kg.The study suggested that preventive effect of Ge-132 on chemically induced carcino-genesis was closely correlated with the dose of Ge-132 used.

关 键 词：有机锗 量效关系 大鼠 大肠肿瘤 

分 类 号：R979.1[医药卫生—药品]