加味补阳还五汤对周围神经再生的形态学实验研究  

A morphological experimental study on the promoting effects of modified Decoction Invigorating Yang for Recuperation on peripheral nervous regeneration

作　　者：赵翠萍[1] 王健智[1] 孙娟[1] 秦刚喜 许保军[1] 赵然[1] 

机构地区：[1]河南省洛阳正骨医院正骨研究所,471002

出　　处：《中医正骨》1993年第2期6-8,共3页The Journal of Traditional Chinese Orthopedics and Traumatology

摘　　要：用钳夹法造成大鼠腓总神经损伤动物模型,灌胃给加味补阳还五汤进行治疗。研究结果显示:用药组再生神经轴索数和损伤神经再生率明显高于对照组P<0.05～0.01;用药组类似正常结构的髓鞘数目多;雪旺氏细胞增殖活跃;失神经肌萎缩程度轻。表明加味补阳还五汤对神经纤维再生、雪旺氏细胞活跃增殖、髓鞘形成及结构完整有明显促进作用。对失神经性肌萎缩有改善作用。为用中医中药治疗神经损伤提供了科学依据。Animal models of rat common-peroneal-nerve injury were made with forceps～holding method and treated by modified Decoction Invigorating Yang for Recuperation (DIYR) given through the stomach.. The results of the study showed: (1)the axon number of regenerative nerves and the regenerative rate of injured nerves in drug groups were significantly higher than those of the contrls (P<0.05～0.01); (2) the number of paranormal madullary sheaths of the test groups was greater; (3) Schwann's cells in the test groups reproduced more actively; (4) the degree of the muscular atrophy without innervation was slighter. That suggested that DIYR has the significant stimulative effests on nerve fibrae regeneration, Schwann's cells reproduction, madullary sheath formation and structural perfect. The drug can also improve the muscular atrophy without innervation. This study could offer a scientific basis for TCM treatment of nerve injury.

关 键 词：神经损伤 神经再生 补阳还五汤 

分 类 号：R277.7[医药卫生—中医学]