乳糖酶缺乏的间接诊断法(乙醇乳糖耐量试验血、尿半乳糖测定法)  

INDIRECT DIAGNOSTIC METHODS FOR LACTASE DIFFICIENCY

作　　者：赵聪敏[1] 李为明[1] 杨颖 

机构地区：[1]第三军医大学新桥医院

出　　处：《重庆医学》1993年第6期324-326,共3页Chongqing medicine

摘　　要：乳糖酶缺乏(LD)是儿童和成人的常见疾病,确定诊断最可靠的方法是小肠粘膜活检直接测定酶活性,然而其侵入性难以作为常规手段应用。本文旨在通过血和尿半乳糖测定建立一LD的间接诊断法。在受试者口服含乳糖和乙醇150mg/kg溶液时,于空腹和乳糖负荷后40分钟分别采静脉血、毛细血管血和尿液各一次测定半乳糖浓度。血半乳糖<0.3mmol/L、尿半乳糖<2mmol/L诊断为LD。试验表明本法简便可信,可做为LD的间接诊断法供临床选用。Abstract: Lactase Difficiency (LD) is common in children and adults. The most reliable way to diagnose the disorder is to determine lactase activity in a tissue sample obtained by small-bowel biopsy, but, under- standably, this cannot be routine practic. The purpose of this study was to develop a simple test of serum and urinary galactose for the indirect diagnostic methods of LD. The subjects were given a solution containing Lactose and 150 mg etbanol/Kg body weight orally at the same time. The venous, fingertip blood and uri- nary samples of the subjects were obtained at fasting-state and 40 minutes after the lactose ingestion and galactose of samples was measured. LD is diagnosed when B-galactose is<0.3 mmol/L or U-galactose is< 2 mmol/L. The results suggest that the galactose measured is as reliable. This test may be recommended for the diagnosis of LD.

关 键 词：诊断 乳糖酶缺乏 半乳糖 测定 

分 类 号：R725.915[医药卫生—儿科]