RAAS、ANF、ERPF和24小时尿钠在心力衰竭中的改变及相互关系  

CHANGES OF RENIN-ANGIOTENSIN-ALDOSTE RONE SYSTEM, ATRIAL NATRIURETIC FACTOR,EFFECTIVE RENAL PLASMA FLOW AND 24h URINE SODIUM IN PATIENTS WITH HEART FAILURE AND THEIR CORRELATIONS

作　　者：凌宗秀[1] 殷跃辉[1] 罗开良[1] 李增高[1] 李德旺[1] 张万钟[2] 陈太弟[2] 庞久高[2] 

机构地区：[1]重庆医科大学第二医院心内科 [2]重庆医科大学同位素科

出　　处：《重庆医科大学学报》1993年第1期11-14,共4页Journal of Chongqing Medical University

摘　　要：用放免法测定110例心力衰竭(CHF)患者及35例正常人的肾素(PRA)、血管紧张素(A_Ⅰ)、醛固酮(ALD)、心钠素(ANF)、有效肾血流量(ERPF),部分人测定尿钠/24h。结果显示CHF时ERPF、尿钠/24h明显下降,PRA、A_Ⅰ、ALD和ANF明显增高,并随心衰加重改变愈著,尤以肺心病最著。CHF时PRA、A_Ⅰ、ALD呈正相关;PRA与ERPF负相关,与尿纳/24h不相关;ERPF、尿钠/24h与ALD不相关,与A_Ⅰ负相关;ANF与ERPF负相关,与尿钠/24h、PRA、A_Ⅰ和ALD不相关。Plasma renin activity (PRA), angiotensin II (ANG II), aldosterone (ALD), atrial natriuretic factor (ANF) and effective renal plasma flow (ERPF) were measured with methods of radioimmunoassay in 110 patients with heart failure and in 35 normal controls, 24th urine sodium significantly decreased and ANG II, ALD ANF apparently increased in patients with heart failurne, especially in those with cor pulmonale. The value of above determines was well correlated with the severity of heart failure, suggesting that they can be used as marks of heart failure severity.There was a possiuvive correlation among PRA, ANG II and ALD, and a negative correlation Ibetween PRA and ERPF, which consisted with pathophysiologic mechanisms of heart failure. Compared PRA with 24h urine sodium, ALD with ERPF, respectively, no correlations were demonstrated. Paro-doxically there was a negtive correlation between ANF anbd ERPF, ANG II with ERPF and 24h urine sodium, Tdese findings show that neurohumoral regulation is disturbed in heart failure

关 键 词：肾素 血管紧张素 醛固酮 心力衰竭 

分 类 号：R541.610.2[医药卫生—心血管疾病]