尼尔雌醇对绝经后子宫内膜影响的观察  

An Observation on khe Effect of Nylestriol on Postmenopansal Uterine Endometrium

作　　者：刘建立[1] 程国钧[1] 樊薇[1] 叶惠方[1] 张全[1] 陈乐真[2] 王志清[3] 潘和平[3] 

机构地区：[1]解放军总医院妇产科 [2]军医进修学院病理科 [3]军事医学科学院放射医学研究所

出　　处：《军医进修学院学报》1993年第1期14-16,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：139例服用尼尔雌醇(Nylestriol,CEE_3)的绝经后妇女于服药前、服药后6个月、12个月及36个月作子宫内膜检查,共取内膜205次。结果发现GEE_3可以引起子宫内膜增生及突破性出血,2mg组较1mg组影响显著,但其发生比例低于文献报导的结合雌激素服用者。增殖的内膜中出现纤毛细胞;服药12个月的内膜刮出率不高于用药6月,36个月后未刮出内膜,可能是CEE_3的内膜增殖作用较弱,及定期加用孕激素后子宫内膜增生延迟的结果。Curettages were performed in 139 postmenopausal women before, and 6 months, 12 months and 36 months after Nylestriol (CEE3)therapy. It was found that CEEE_3 might induce endometrial proliferation and uterine breakthrough bieeding, and more so in women using 2mg of CEE_3 than in those using ling. The incidence of proliferation in our group was lower than in those women having conjungated estrogen therapy as reported in the literature. Ciliated cells were present in the proliferative endometrium after CEE_3. the success rate of obtaining endometrial curettings in women after 12 months' therapy was not higher than alter 6 months. No curetting obtained 36 months after therapy may be explained by CEE_3 having a weaker effect on the endometrium and the regular additional doses of progestin postponing endometrial proliferation.

关 键 词：雌激素 治疗 绝经 子宫内膜 

分 类 号：R711.51[医药卫生—妇产科学]