戊烷脒-EVA骨架释放体系的研究——EVA的弹性模量对释放的影响  

Controlled release of pentamidine isethionate from ethylene-vinyl acetate matrices: effect of elastic modulus of ethyl ene-vinyl acetate copolymer

作　　者：叶卫平 杨纪元 徐晨 陈先丽 

机构地区：[1]北京国家计划生育委员会科学技术研究所,100081

出　　处：《生殖医学杂志》1993年第1期42-45,共4页Journal of Reproductive Medicine

摘　　要：本文报道抗纤溶剂戊烷脒从乙烯-醋酸乙烯酯(EVA)骨架体系中的释放行为。戊烷脒对EVA的渗透系数(D)及稳态流量(J_(lim))的测定结果表明释放机理是溶解控制释放。用EVA-琼脂骨架体系进行了溶胀实验,溶胀速率和溶胀程度随EVA的弹性模量而变化,较小的弹性模量得到较高的溶胀度从而导致较高的释放速度。弹性模量是影响EVA骨架体系药物释放速度的重要因素。Pentamidine isethionate (PI) was selected as an antifibrinolytic agent with a copolymer of ethylene -vinyl acetate (EVA) as its carrier. The steady state flux (J_(lim)) and diffusion coefficient (D) of PI through EVA membranes were determined using a permeation cell. The amount of PI diffusing through the membrane was smaller as compared with that from porous matrix. The release is dissolution controlled. A swelling test using EVA-agarose matrices were conducted to investigate the relationship of mechanical properties with the swelling. The swelling rate and degree are inversely proportional to the elastic modulus of EVA copolymers. The lower elastic modulus with the higher porosity of the matrix was obtained thus enhancing the drug release rate. The elastic modulus is a sensitive and basic factor in affecting the release kinetics.

关 键 词：宫内节育器 戊烷脒 EVA 骨架释放体系 弹性模量 

分 类 号：R169.41[医药卫生—公共卫生与预防医学] R979.21