生育力正常男性精浆中一些附睾功能性指标相关性的研究  

Study on the concentration of glycerol-3-phosphorylcholine,L-carnitine and activity of α,1-4 glucosidase in seminal plasma from fertitle Chinese

作　　者：丁之德[1] 董赛珍[1] 鲁梅格[1] 吴明章[1] 

机构地区：[1]上海第二医科大学组织胚胎教研室,200025

出　　处：《生殖医学杂志》1993年第2期72-75,共4页Journal of Reproductive Medicine

摘　　要：我们对50例生育力正常男性精浆中甘油-3-磷酸胆碱(GPC)、肉毒碱含量及α,1-4糖苷酶活力依次进行测定,结果显示:精浆中 GPC 与肉毒碱含量及α,1-4糖苷酶活力分别为2.32±0.65mmol/L、233.95±85.69μmol/L 及41.17±21.27IU/L,三者均呈显著正相关(P<0.01)。总量及总活力分别为7.35±3.04μmol/总毫升数、741.77±301.52nmol/总毫升数及133.93±88.35mIU/总毫升数(±s)。GPC、肉毒碱及α,1-4糖苷酶与精子在附睾内发育成熟均存在密切的联系,作为附睾重要的功能性指标,精浆中 GPC、肉毒碱含量及α,1-4糖苷酶活力的测定对附睾疾病的诊断与治疗都具有十分重要的意义。Some markers of epididgmal function——glycerol-3-phosphorylcholine(GPC),L-carni- tine concentration and α,1-4 glucosidase activity were detected in seminal plasma from 50 fertile Chinese and their correlation were studied.The mean values of semen GPC,L-carnitine concentration and α,1-4 glucosidase activity were 2.32±0.65mmol/L,233.95±85.69μmol/L and 41.17±21.27 IU/L,and the total values of them were 7.35±3.04μmol/ejaculate,741.77±301.52nmol/ejaculate, and 133.93±88.35 mIU/ejaculate(±s)respectively.A significant positive correlation has been found between the concentrations of GPC and L-carnitine,the concentration of GPC and the activity of α,1-4 glucsidase(P<0.01). As a measure of epididymal function,the physiological roles of the GPC,L-carnitine and α,1-4 glu- cosidase related to the development and maturation of the sperm during epididymal transit have been discussed.

关 键 词：甘油 磷酸胆碱 肉毒碱 糖苷酶 精浆 附睾功能 

分 类 号：R339.21[医药卫生—人体生理学]