儿童胸腺在各种疾病中的改变——Ⅱ.儿童退化胸腺内的微环境改变——组织学、免疫组化和超微结构研究  

Changes of Children Thymuses in Different Diseases——Ⅱ. Changes of Microenvironment of Involuted Thymuses in Childhood: Histological, Immunohistochemical and Ultrastructural Study

作　　者：梁生本 章敏[1] 李仁[1] 赵振武 王延复 于东海 周莉 

机构地区：[1]哈尔滨医科大学病理学教研室 [2]哈尔滨市红十字儿童医院病理科

出　　处：《哈尔滨医科大学学报》1993年第3期177-181,F004,共6页Journal of Harbin Medical University

摘　　要：本文对70例退化胸腺进行了组织学、角蛋白和S-100蛋白的免疫组化和超微结构的观察。胸腺退化时发生上皮细胞的退行性改变和树突状细胞的数量减少,表明胸腺细胞分化发育的微环境发生了改变。因此上皮细胞和树突状细胞的改变比胸腺细胞具有更重要的意义。巨噬细胞的吞噬作用可能不是胸腺清除退变死亡胸腺细胞的主要方式。70 involuted hymuses obtained at autopsy from children died of different diseases were studied with histological, immunohistochemical and ultrastructural approaches。In the immunohistochemical study, antibodies against keratin and S-100 protein were used. Our findings suggest that the thymic involution is usually accompanied by the damage of thymic microenvironments which includes the degeneration of epithelial cells and the decrease in number of dendritic cells in thymuses. Therefore, the changes of epithelial cells and dendritic cells are more important than the decrease in number of the thymocytes in the involuted thymus. Phagocytosis of macrophages might not be the main way to eliminate the degenerative and died thymocytes.

关 键 词：胸腺 退化 超微结构 巨噬细胞 

分 类 号：R726.557[医药卫生—儿科]