腹主动脉分叉处粥样斑块分布及其意义  

A STUDY ON THE DISTRIBUTION OF ATHEROSCLEROSIS AT THE BIFURCATION OF ABDOMINAL ARTERIES

作　　者：王克强[1] 杨俊华[2] 吴国强[3] 于彦铮[1] 肖子顺 黄德桥[1] 施建英[2] 

机构地区：[1]上海医科大学基础医学部人体解剖学 [2]上海医科大学病理解剖学 [3]上海医科大学生物医学工程教研室 [4]上海徐汇区卫生学校

出　　处：《上海医科大学学报》1989年第6期427-430,共4页Journal of Fudan University(Medical Science)

摘　　要：动脉粥样硬化损害分布与动脉开口、分支有关。对39例尸体腹主动脉分叉处粥样斑分布进行观察及对7例左、右髂总动脉(有斑块)作1mm厚的连续横切,通过微机进行统计分析,发现左、右髂总动脉内斑块分布,均以分叉的内侧壁面为多。左、右侧分别占病变例数90％、93％。在病变血管中可见管壁内侧增厚的新月型斑块。从流体力学分叉管处的速度剖面可知,分叉管内侧壁面切应力高于外侧。这与粥样斑形成的高切应力理论相吻合。高切应力对内皮的损伤可看作是早期粥样斑块形成的始动因素之一。The distribution of the damaging site caused by atherosclerosis is related to tlie opening and branching of the artery. The distribution of atherosclerotic plaques of the bifurcation of the abdominal aorta in 39 cadavers were observed, consecutive cross-sections at 1mm thicknesses of 7 left and right common iliac arteries were made, statistical analysis of data in an IBM PC microcomputer showed that plaques are mainly located on the medial aspects of the left and right common iliac arteries at their bifurcation (90%, 93% respectively). The plaques appear crescent shaped. The shearing force-is greater on the medial wall than the lateral wall. Our discovery concurs with the theory of the effects of high shearing force in atherosclerotic plaque formation. Early plaque formation can be considered as one of the initial factors in endothelial damage.

关 键 词：动脉粥样硬化 切应力 腹主动脉分叉 

分 类 号：R543.502[医药卫生—心血管疾病]