氟对大鼠肝细胞影响及SOD阻断因子的透射电镜研究  

Effect of fluorine and superoxidase on the rat hepatocyte ultrastructure

作　　者：边晓燕[1] 吴振铎[1] 李红[1] 张亚坤[1] 王志成[2] 吴莹[2] 关德宏[2] 闫景龙[2] 石玉霞[3] 富德[3] 

机构地区：[1]哈尔滨医科大学电镜室 [2]哈尔滨医科大学附属二院 [3]中国地方病防治研究中心氟病所

出　　处：《中国地方病学杂志》1993年第3期136-137,F003,共3页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金

摘　　要：本实验分正常组、投氟组、投氟加超氧化物歧化酶(SOD)组喂养大鼠六个月后处死,制作肝组织的透射电子显微镜标本,进行超微结构观察。结果发现,投氟组肝细胞产生明显的毒性作用,表现为肝细胞肿胀,细胞膜破损,线粒体变性,核形不整、固缩,一些肝细胞崩解。在投氟加 SOD 的两种喂养方法中,一组肝细胞出现一些可逆性损伤,而另一组肝细胞结构与正常组近似。提示 SOD 作为抗氧化剂对食入大剂量氟的大鼠肝细胞有保护作用。This experiment was divided into con-trasted group,fluorinated (F) group and fluo-rinated together with superoxidase (SOD)group.After feeding the rats for six monthes,they were put to death and took the liver tis-sue for TEM specimen.the resaults of ultra-structural observation showed that the hepato-cytes injury,cellular edema mitochondrialswelling necrosis and so on,were evident inthe fluorinated group.In the other two groupsof F+SOD,one group appeared some re-versible injury and another was similar to con-trasted group,which indicated SOD could pro-tect rat liver from the injury b(?) the fluorine.

关 键 词：氟 肝细胞 超微结构 超氧物歧化酶 

分 类 号：R599.902[医药卫生—内科学]