卡氏肺孢子虫的超微结构观察  

OBSERVATIONS ON THE ULTRASTRUCTURE OF PNEUMOCYSTIS CARINII

作　　者：苏天成[1] 杨林[1] 

机构地区：[1]湖北医学院寄生虫学教研室,武汉430077

出　　处：《中国寄生虫病防治杂志》1993年第1期30-32,T003,共4页Chinese Journal of Parasitic Disease Control

摘　　要：采用皮下注射醋酸可的松和低蛋白饲养方法诱发SD大鼠自然感染卡氏肺孢子虫后,取其肺组织,按常规方法进行透射电镜的系统观察。结果除为Yoshida提出的卡氏肺孢子虫生活史的有性增殖和无性增殖循环的最新设想提供了某些形态学依据外,还继Vossen等之后再次发现该病原在1型肺泡上皮细胞内寄生的情况。本文最后就卡氏肺孢子虫对宿主的致病机理进行了讨论。SD rats were infected with P. carinii by injecting cortisone acetate subcutaneously and feeding with low protein diet. The specimens were prepared with the routine procedures and the ultrastructure were examined by trasmission electron microscopy. Three forms of the parasite, i. e. trophozoite, precyst and cyst of P. carinii can be seen in rat alveoli. There were observed synaptonemal complexes in the precyst of uninuclear cell besides the nuclear divisions. cell delimitation, intracystic bodies in the precyst and binary fissions of tropho- zoites. These results supported the current idea that the life cycle of P. carinii included both a sexu- al and an asexual mode of multiplication. Previous studies of experimental infections with Pneumocystis organisms have noted tropho- zoite forms lining the alveolar walls attached to the type I pneumocytes. We have also noted trophozoites inside the alveolar epithelial cells as described by Vossen et al. Finally, the pathogenecity of this parasite to the host was discussed primarily.

关 键 词：卡氏肺孢子虫 超微结构 病理 

分 类 号：R382.3[医药卫生—医学寄生虫学]