乳腺疾病患者血液中催乳素、雌二醇和孕酮值的测定结果及其意义  

SERUM PROLACTIN, ESTRADIOL AND PROGESTERONE IN MASTOPATHIES AND THEIR SIGNIFICANCE

作　　者：李玉珠[1] 朱锡琪[1] 庄清萍[1] 任长才[1] 查良伦[1] 蔡文炜 谢玲玉[2] 

机构地区：[1]上海医科大学附属华山医院外科 [2]上海医科大学卫生学院卫生统计教研室

出　　处：《上海医学》1989年第4期197-200,共4页Shanghai Medical Journal

摘　　要：作者测定了9.17例乳腺疾病患者的泌乳素(PRL)、雌二醇(E_2)和孕酮(Prog)值,发现各组患者的PRL值均在正常范围,而各组患者的Prog值均明显降低,尤以40～49岁的乳癌患者的Prog值降低特别明显。乳腺良性疾病组与乳癌组的E_2值也均明显低于正常范围,并随年龄的增长更为显著。作者初步认为,各种乳腺疾病包括乳腺癌的发病与激素的内环境的异常有一定的关系,其中Prog值的降低可能具有更大的致病作用。但其确切的发病机理有待近一步探索。The serum levels of prolactin, estradiol and progesterone in 217 patients with various kinds of benign and malignant mastopathies were measured by radioimmunoassay. The data indicated that the prolactin values were normal while the progesterone levels were decreased significantly in all of the groups. The estradiol values were also markedly reduced in patients with fibrocystic mastopathy and breast carcinoma. Although the pathogenesis of breast disease remains to be elucidated, the present finding suggests that the low estradiol level, particularly the lowered progesterone level may be an important causative factor.

关 键 词：乳腺病 催乳素 雌二醇 孕酮 

分 类 号：R655.804[医药卫生—外科学]