对甲基叔丁醚及其乳剂毒性的研究  

TOXICITIES OF METHYL TERTIARY BUTYL ETHER AND ITS COMPOUND EMULSION

作　　者：郭绍红[1] 张圣道[1] 牛妞 施瑞庭 姜志宏[1] 张明钧 徐淑华[1] 傅培彬 

机构地区：[1]上海第二医科大学附属瑞金医院外科

出　　处：《上海医学》1989年第8期472-476,共5页Shanghai Medical Journal

摘　　要：甲基叔丁醚(MTBE)是一种新型灌注溶石药物,本文报告了对MTBE及其乳剂(HCMT)动物毒性较系统的研究结果。实验测得昆明种小白鼠胃灌注、腹腔注射、静脉注射MTBE的LD_(50)分别为5.96、1.70、0.25ml/kg;昆明小白鼠胃灌注HCMT的LD_(50)为11.53mI/kg。鼠、兔、狗动物实验发现MTBE与HCMT能造成动物溶血、皮下组织水肿坏死、结膜充血水肿、神经麻痹、肝细胞混浊肿胀凝固性坏死、胆囊和胆管急性炎症、十二指肠乳头水肿、肠粘膜急性炎症等不同毒性表现。HCMT毒性略低于MTBE。作者认为:MTBE毒性较大,用于胆囊结石灌注溶石时应十分慎重,不允许MTBE进入非胆道系统的任何组织,不赞同将MTBE应用于胆管结石的灌注溶解治疗。Methyl tertiary butyl ether (MTBE) is a new and powerful solvent for cholesterol gallstone. It was found that MTBE was toxic when used in patients. We studied the toxicities of MTBE and its compound emulsion, HCMT (H_2O-1, 2-cyclohexanediaminetetraacetic acid—MTBE—Triton X-100 emulsion) on animals. The LD_(50) of gastric lavage, peritoneal cavity injection and intravenous injection of MTBE in mice were 5.96, 1.70 and 0.25 ml/kg respectively. The LD_(50) of HCMT lavage in mice was 11.53 ml/kg. In dog, rabbit and mouse, MTBE and HCMT might cause untoward reactions like hemolysis, nerve paralysis, acute cholecystitis, hepatic cell cloudy swelling and focal necrosis, and acute duodenitis. Our conclusions are that the toxicities of MTBE and HCMT are serious; their clinical use should be extremely cautious; and they should not be injected into any tissues other than gallbladder, even the bile duct,.

关 键 词：甲基叔丁醚 乳剂 毒性 

分 类 号：R965.3[医药卫生—药理学]