从临床、免疫、病理探讨甲状腺机能亢进与桥本氏甲状腺炎的关系——附102例分析  

RELATIONSHIP BETWEEN GRAVES' AND HASHIMOTO'S DISEASES: CLINICAL 1MMUNOLOGICAL AND PATHOLOGICAL ANALYSIS OF 102 CASES

作　　者：陆广华[1] 江绍基[1] 袁济民[2] 李进禧[1] 陈曙霞[1] 刘淑明[1] 徐国雄[1] 李敏[2] 张庆怡[1] 戴蔼善 汤一麟 陈姮[3] 承解静[3] 

机构地区：[1]上海第二医科大学附属仁济医院内科 [2]上海第二医科大学附属仁济医院核医学科 [3]上海市普陀区中心医院内科 [4]上海市普陀区中心医院外科

出　　处：《上海医学》1989年第9期509-512,共4页Shanghai Medical Journal

摘　　要：Graves甲状腺机能亢进(GD)102例,病程为1月～20年,经甲状腺细针穿刺细胞学检查结果,1例仍报告为GD,41例报告符台桥本氏甲状腺炎(HT)。该41例按上皮细胞退化变性和淋巴细胞浸润程度又分成三个类型。并结合同对检测的抗甲状腺球蛋白抗体(TGA),抗甲状腺微粒体抗体(TMA)分析,提示GD病程愈长,抗体水平愈高者,转变为HT的可能性愈大。涂片所见上皮细胞退化、变性和淋巴细胞浸润程度也愈严重。作者认为GD和HT关系密切,可以互相转变,很可能是同一种疾病的两种不同临床类型。One hundred and two cases of Graves' disease (GD) are reported. Their clinical course lasted from one month to 20 years. Histologic examinations of biopsy specimens (through fine-needle puncture) of the glands were compatible with the diagnosis of GD in 61 cases. In other 41 cases, the pathological pictures were consistent with Hashimoto's disease(HT) which can be classified into three types according to the degree of epithelial cell degenerative changes and lymphocytic infiltrations. Parallel studies of anti-thyroglobulin and anti-microsomal antibodied showd that the longer the course of the disease, the higher the antibody levels and the more the epithelial cell damage and lymphocytic infiltra tion. The above findings together with relevant reports elsewhere suggest that a close relationship exists between GD and HT. They might be two interchangeable phases of avingle disease entity with different clinicopathological manifestations.

关 键 词：甲亢 甲状腺炎 免疫学 病理 

分 类 号：R581.103[医药卫生—内分泌]