哮喘患者家族气道反应性的观察  

OBSERVATION ON AIRWAY-RESPONSIVENESS IN KINSFOLK OF ASTHMATIC PATIENTS

作　　者：章晓冬[1] 汪敏刚[1] 俞霞珍 张瑞芳[1] 

机构地区：[1]上海医科大学附属华山医院内科呼吸哮喘组

出　　处：《上海医学》1989年第12期694-696,共3页Shanghai Medical Journal

摘　　要：本文用组织胺吸入试验测定了33例缓解期哮喘患者、40例哮喘患儿双亲及3量侧正常儿童双亲的气道反应性。结果,哮喘组气道反应性最高,PC_(20)均小于3mg/ml,平均为0.59mg/ml(0.125～2.6mg/ml),对照组最低,PC_(20)均大于32mg/ml,而哮喘患儿双亲组介于两者之间,平均为11.6mg/ml(0.71～32mg/ml)。另外,过敏性鼻炎及荨麻疹患者的气道反应性也显著高于正常人,平均PC_(20)分别为3.1mg/ml和14.3mg/ml。以上结果提示哮喘患者家族成员可能是哮喘的易患人群。Bronchial responsiveness to histamine was measured in 33 asymptomatic asthmatic children, 40 parents of asthmatic children and 34 parents of healthy children (control). The results showed that the airway responsiveness of asthmatic children was the highest, all PC_(20) values were less than 3mg/ml with an average of 0.59mg/ml (0.125-2.6mg/ml) and that of the control group was the lowest, all PC_(20) values were more than 32mg/ml. However, the patients' parents group had medium, responsiveness average PC_(20) 11.6 mg/ml(0.71-32mg/ml). In addition, the airway responsiveness of the patients with allergic rhinitis and urticaria was higher than the normal persons, average PC_(20) 3.1mg/ml and 14.3 mg/ml respectively. These findings showed that the kinsfolk of asthmatic patients are the population susceptible to asthma.

关 键 词：哮喘 家族 气道反应性 

分 类 号：R652.250.2[医药卫生—外科学]