碱性成纤维细胞生长调节因子对家兔皮肤创伤愈合的影响  

THE EFFECT OF BASIC FIBROBLAST GROWTH FACTOR (bFGF) ON WOUND HEALING OF RABBIT BACK SKIN

作　　者：杨美玲[1,2] 

机构地区：[1]暨南大学药理教研室 [2]暨南大学生物学系

出　　处：《暨南大学学报（自然科学与医学版）》1993年第1期109-112,共4页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：暨南大学生物系林剑教授所属85攻关项目的分题

摘　　要：探讨碱性成纤维细胞调节因子(bFGF)对家兔背部皮肤创伤的促愈合作用,治疗组采用10μg/ml、3μg/ml、μg/ml3种不同浓度的bFGF;对照组采用溶媒和生理盐水。以手术刀切割家兔背部皮肤,造成局部创伤以观察bFGF疗效。结果表明,bFGF能促进创面干燥,痂皮形成早,脱痂早,与两个对照组相比,在涂药第13天时,其自然脱痂时间(愈合率)与溶媒组相比有显著性差异(P<0.05)。在3种不同浓度的bFGF组中以3μg/ml组脱痂最早,提示该浓度可能是治疗家兔皮肤局部创伤的理想浓度。The effect of bFGF on wound healing of rabbits back skin. To the treatment groups: three level of concentration bFGF (10μg/ml, 3μg/ml, 1μg/ml) were daubed on the wound area of skin respectively. To the control groups: solvent and 0.9％ saline (NS)were daubed instead of bFGF solution. The results showed that bFGF had an accelerating effect of wound healing and scab shedding. The difference between the three treatment groups and the control group that was daubed with solvent were significant(P<0.05)In addition the 3μg]ml group showed the best result, which might be most suitable for the treatment of skin wound.

关 键 词：创伤 伤口愈合 BFGF 皮肤 

分 类 号：R982[医药卫生—药品]