煤焦油烟对作业工人血中超氧化物歧化酶活性及脂质过氧化产物含量影响的研究  

STUDY ON SUPEROXIDE DISMUTASE AND LIPID PEROXIDEOF WORKERS′BLOOD AFFECTED BY COAL一TAR

作　　者：张光成[1] 方思鸣[1] 罗凯 林立 石光明 

机构地区：[1]武汉同济医科大学生物学教研室,武汉冶金医学专科学校,武汉钢铁公司医院

出　　处：《癌变．畸变．突变》1994年第4期18-22,共5页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：本文通过对武钢焦比厂４０名炼焦作业工人和４０名健康人血中ＳＯＤ和ＬＰＯ水平进行研究，结果表明炼焦工人血中ＳＯＤ活性明显低于对照组．差异非常显著（Ｐ＜０．０ｌ）．血清中ＬＰＯ含量明显高于对照组，差异极显著（Ｐ＜０．０ｌ）。同时分析了作业工人的工龄和烟酒嗜好与ＳＯＤ及ＬＰＯ之间的关系．结果都未见有明显差异。ln this paper we studied the change of superoxide dismutase and lipid peroxide of workers′at coking plant.The result shows that superoxide dismutase activity is lower obviously in tesl一group than normal control(P<0. 01), and lipid peroxide concentration of test group is higher significantly than that of normal control( P<0. 01). This suggests that coal一tar can induce to produce free radicals in human. Free radicals cause organism to produce lipid peroxidation , result in high concentration of lipid peroxide. Meanwhile,free radicals also reduce superoxide dismutase activity.In addition,statistical data indicate the ratio of carcinogeneses is higher significantly in worker-touched coal tar than crowd.

关 键 词：职业病 煤焦油 超氧物歧化酶 过氧化脂质 

分 类 号：R598.102[医药卫生—内科学]