叶绿酸抗某些毒物致微核作用的研究  

THE STUDY OF THE BL0CT EFFECT OF CHLOR0PHYLLIN ON MICRONUCLEI FORMATION INDUCED BYSEVERALPOISONS

作　　者：陈雯[1] 詹德进 陈家坤[1] 吴中亮[1] 杜应秀[1] 

机构地区：[1]广州医学院化学致癌研究所

出　　处：《癌变．畸变．突变》1994年第5期59-63,共5页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：本文用双核微核试验法研究叶绿酸对香烟烟雾凝聚物，苯并（ａ）芘、丝裂霉素Ｃ及硫酸镍诱导ＢＡＬＢ／３Ｔ３和ＣＨＬ细胞的微核率的影响。结果发现：叶绿酸有抗香烟烟雾凝聚物，苯并（ａ）芘及硫酸镍诱导微核形成的作用，但对丝裂霉素Ｃ无抑制作用。本文还对叶绿酸抑制微核形成的机理作了讨论。Using the cytokinesis-block(CB)method,this paper studied the effect ofchlorophyllin on the micronuclei formation in BALB/3T3 and CHL。cell lines induced bytobacco smoke condensate(TSC),benzo(a)pyrene B(a) P,nickel sulfate(NiSO2)andmitomycin C(MM.The result showed that chlorophyllin could reduce the micronucleiformation induced by TSC,B(a)P and NiSO2 ,but the block effect could not be found inthe cells treated with MMC。The mechanism of the block effect of chlorophyllin onmicronuclei formation was discussed。

关 键 词：叶绿酸 抗微核形成 抗癌药 

分 类 号：R979.1[医药卫生—药品] R73－361[医药卫生—药学]