大剂量电离辐射对肾素－血管紧张素－醛固酮系统功能的影响  

Effects of large dose X-irradiation on function of renin- angiotensin-aldosterone system

作　　者：龚守良 范冰 周剑 柯勇 

出　　处：《白求恩医科大学学报》1994年第2期136-138,共3页Journal of Norman Bethune University of Medical Science

摘　　要：本研究采用５ＧｙＸ射线全身照射雄性大鼠模型，观察照射后１、２、４和７天血清血管紧张素Ⅰ（ＡＴⅠ）、血管紧张素Ⅱ（ＡＴⅡ）和醛固酮（ＡＬＤ）水平的变化。结果表明，照射后１天血清ＡＴⅠ和ＡＬＤ水平降低，血清ＡＴⅡ水平无变化；照射后２天和４天血清ＡＴⅠ波动在对照组水平，血清ＡＴⅡ水平逐渐增高，而血清ＡＬＤ水平明显低于对照组；照射后７天三者都不同程度高于对照组。提示，大剂量全身照射后初期肾素－血管紧张素－醛固酮系统调节发生紊乱，照射后急期此系统对体内水和电解质失衡产生一种适应性反应。The present study was designed to observe the cganges in serum angiotensin I(AT Ⅰ),angiotensinⅡ(AT Ⅱ)and aldosterone(ALD) levels 1,2,4 and 7d after 5 Gy -ir-radiation in male rats.The results showed that serum ATⅠand ALD levels decreascd l d afterirraddiation,but serum AT Ⅱlevel didn’t change;serum AT Ⅰlevel fluctuated about the controllevel and serum AT Ⅱlevel gradually increased 2 and 4 d after irradiation,while serum ALD lev-el was obviotisly lower than that of the control group; all these three indices increased 7 d after ir-radiation.These results suggested that regulation of renin-angiotensin- aldosterone system was indisorder at the initial stage after whole-body irradiation with large dose of X-rays and the system,in the acute stage after irradiation,produced an adaptive response to the imbalance of water andelectrolvtes within thebody.

关 键 词：全身照射 血管紧张素I 醛固酮 

分 类 号：R818.02[医药卫生—放射医学]