下丘脑向小脑的直接投射——WGA-HRP法研究  

HYPOTHALAMO-CEREBELLAR PROJECTIONS IN THE RAT: WGA-HRP STUDY

作　　者：张欣[1,2] 吕梦翔[1,2] 杨振芳 于志强[1,2] 张殿明 

机构地区：[1]天津医学院解剖学教研室 [2]天津内分泌研究所神经内分泌研究室

出　　处：《神经解剖学杂志》1989年第1期52-54,共3页Chinese Journal of Neuroanatomy

摘　　要：用WGA-HRP逆行追踪大鼠下丘脑到小脑前叶蚓部皮质的直接投射,结果表明下丘脑双侧均可见标记细胞,同侧优势。在下丘脑背侧区室旁核有密集深染的标记细胞,在下丘脑外侧区、后区、交叉后区及下丘脑腹内侧区亦可见到标记细胞,本文结果为小脑对内脏功能调节提供形态学论据。Although it has been suggested that the cerebellum may influence on, or be influenced by, autonomic centers, the anatomy of these potential connections remains enigmatic, The present study provides evidence of a hypothalamo-cerebellar projection in rat. Microinjections of 1.25％ WGA-HRP or HRP were stereotactically placed into the cerebellar cortex(vermis lobules Ⅱ. Ⅲ, Ⅳ, antrior lobe). Following survival times of 24 hours, rats were perfused with 1.0% paraformaldehyde and 1.25% glutaraldehyde. Brains were cut in serial transverse frozen sections at 40 μx and processed using the TMB as the chromogen. In no case did cortical injections involve the cerebellar nuclei. Retrogradely labeled somata were found bilaterally in the hypothalamus with a slight ipsilateral preponderance. The paraventricular nucleus and dorsal hypothalamic area contained the majority of labeled cells. Cell labeling was also seen in lateral, posterior hypothalamic area, retrochiasmatic area and ventromedial hypothalamic nucleus. These results indicate a direct connection between hypothalamus and the cerebellar cortex.

关 键 词：下丘脑 WGA-HRP 小脑 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]