加味当归补血汤及枸杞子对TH细胞缺陷小鼠的实验治疗  

THE EXPERIMENTAL STUDY ON DANGGUI BUXUE TANG WITH ADDITIONAL INGREDIENT AND LYCIUM BARBARUM TREATMENT IN TH IMMUNODEFICIENCY MICE

作　　者：殷金珠[1] 李志新[1] 白惠卿[1] 李云贵[1] 白小薇[1] 宋海峰 

机构地区：[1]北京医科大学免疫学教研室

出　　处：《北京医科大学学报》1994年第1期10-12,共3页Journal of Peking University(Health Sciences)

基　　金：美国洛氏基金

摘　　要：实验性ＴＨ细胞缺陷小鼠口饲加味当归补血汤（ＢＴ）和枸杞子（ＬＢ）２周后，其免疫功能得到明显改善，表现为：（１）脾细胞对ＣｏｎＡ，ＬＰＳ的反应性及自然增殖率明显高于未治疗免疫缺陷组（ＩＤ），Ｐ＜０．０１；（２）ＭＬＲ：ＢＴ组提高１．６倍，ＬＢ组提高３．６倍；（３）对ＴＤ抗原的免疫应答，ＩｇＧ、ＩｇＥ抗体应答及ＤＴＨ都显著高于ＩＤ组；（４）ＣｏｎＡ活化的脾细胞对外源性ＩＬ－２的反应性大大高于ＩＤ组，接近正常对照小鼠。ＢＴ和ＬＢ还可增强正常小鼠的免疫功能。The immunodeficiency mice treateed with Danggui Buxue Tang with additional ingredient(BT)and Lycium Barbarum (LB)for two weeks have shown that:(1) The responsiveness of spleen cells to mi- togens (Con A,LPS) and spontaneous proliferation are promoted markedly (P>0.01).(2)Respon siveness significantly increased in splenocytes activated by Con A to rhIL-2.(3)The MLR was incre-ased 1.6 fold(BT)and 3.6 fold(LB).(4) Both BT and LB improved the development of T dependentantibody (IgG, IgE)formation and delayed hypersensitivity reaction significantly (5)LB caused a re-storation of CD4+ cells to CD8+ cells ratio in lymph nodes. Normal mice treated with BT or LB haveshown that the responsiveness;of splenocytes to Con A or SRbc ebviously increased as well.

关 键 词：当归补血汤 枸杞子 免疫缺陷 

分 类 号：R285.5[医药卫生—中药学]