几种咪唑类外用抗真菌药接触性皮炎的初步研究  

CONTACT DERMATITIS DUE TO SOME TOPICAL IMIDAZOLE ANTIFUNGAL DRUGS

作　　者：李林峰[1] 王宝华[1] 孙祥银[1] 林幼青 陈学荣[1] 李世荫[1] 

机构地区：[1]北京医科大学第三医院皮肤科,山东省潍坊市皮肤病防治所,湖北医科大学第二附院皮肤科,福建省南平市皮肤病防治院

出　　处：《北京医科大学学报》1994年第4期284-286,共3页Journal of Peking University(Health Sciences)

摘　　要：用３种常用外用咪唑类抗真菌药，达克宁霜（咪康唑）、联苯苄唑霜及癣敌软膏（益康唑）对１８５例有外用此类药物史的皮肤病病人进行了斑贴试验。结果斑试刺激反应及过敏反应阳性率分别为３．８％及４．３％，说明此类药物是常见的致敏原及刺激原之一。抗真菌剂致敏可出现急性接触性皮炎，应与真菌病加重相鉴别。斑贴试验可以诊断抗真菌剂接触性皮炎，并区分刺激反应与过敏反应。Three commonly used topical imidazole antifunga drugs, miconazole nitrate cream, bifonazolecream and econazole nitrate ointment were patch tested in 185 randomly selected skin disease patientswho had used at least one kind of imidazole before. The positive rate is3.8%and 4.3%for irritantand allergic reactions respectlvely. The results indicated that when deterioration was found during theimidazole treatment, contact dermatitis should be considered and patient should be patch tested.

关 键 词：皮炎 抗真菌药 咪唑类 接触性皮炎 药物疗法 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]