糖耐量减低及糖尿病患者的血液粘度变化  

The Alteration of Blood Viscosity in Cases with Iuspaired Glucose Tolerance (IGT)and with non-insulin Dependent Diabetes Mellitus(DM)

作　　者：倪惠兰[1] 郑淑香[1] 沈慧安[1] 施莉莉 

机构地区：[1]北京同仁医院干部医疗科

出　　处：《北京医学》1994年第1期14-17,共4页Beijing Medical Journal

摘　　要：本文观察了６０例ＩＧＴ患者血液粘度及生化指标等，并与正常组４３例、ＤＭ（糖尿病）组，１００例进行比较，ＩＧＴ组全血粘度、血浆粘度、血糖、血脂、纤维蛋白原均高于正常组，以高切变率的全血粘度、血浆粘度、血糖、血脂增高明显（Ｐ＜０．０１）．与ＤＭ组比较，ＩＧＴ组血液流变学及生化指标均低于ＤＭ组，以低切变率下的全血粘度、纤维蛋白原、血糖、糖化血红蛋白降低明显（Ｐ＜０．０１）．提示ＩＧＴ患者及ＤＭ患者除生化改变外，尚有不同程度的血液流变学异常。ｐ＜０．０１表２　ＩＧＴ组与ＤＭ组血液流变学及生化测定结果三、ＩＧＴ组与ＤＭ组比较，ＩＧＴ组４个切变率的全血粘度、血浆粘度、血糖、血脂、纤维蛋白原、糖化血红蛋白均低于ＤＭ组，血液流变学检测指标以低切变率１Ｓ－１最明显，有极显著性差异。纤维蛋白原、血糖、糖化血红蛋白亦低于ＤＭ组，有显著性差异（表２）。四、ＩＧＴ组与ＤＭ组甲襞微循环比较，ＩＧＴ组患者甲襞微循环血流速度较ＤＭ组快，且血管样的输入支、输出支、袢顶的宽度及畸形血管数均低于ＤＭ组，但两组间比较差异无显著性。讨论一、糖尿病是可以累及全身各个脏器的综合性疾病，尽管糖尿病的代谢机理及真正病因还不太清楚，但人们一致认为在病程中存在?The blood viscosity and biochemistry test in 60 cases with IGT were measured and compared with those in DM (100 cases) and normal adult (43). The results revealed that the whole blood viscosities at various shear rates, plasma viscosity, blood sugar, blood lipid and fibrinogen were higher than those in normal group, especially the whole blood viscosity at high shear rate, plasma viscosity, sugar and lipid (P<0.05￣0.01). However, these data in IGT group were lower than in DM group, and the whole blood viscosity at low shear rate, firbrinogen, sugar and glycosylated hemoglobin (GHB) were markedly reduced than in DM (P<0.05￣ 0.01). It is suggested in subjects with IGT and DM there are abnormalities not only in biochemistry, but also in hemorrheology.

关 键 词：糖尿病 糖耐量减低 血液流变学 

分 类 号：R587.1[医药卫生—内分泌]