PVN和脑刺激镇痛关系初探  

INVESTIGATION OF THE RELATIONS BETWEEN PVN AND ANALGESIA VIA INTRABRAIN STIMULATION

作　　者：崔存德 亢国英 张虹 张慧 

出　　处：《滨州医学院学报》1994年第2期101-104,共4页Journal of Binzhou Medical University

摘　　要：用４％水合氯醛麻醉大鼠，在下丘脑室旁核（ＰＶＮ）、中脑导水管周围灰质（ＰＡＧ）埋藏双极刺激电极或不锈钢管，以便刺激、损毁或电泳药物，并暴露脊髓背角，利用微电极记录脊髓背角神经元对伤害刺激坐骨神经单位反应。实验观察到：（１）电刺激ＰＶＮ或注射盐酸吗啡可使大鼠痛阈显著升高。微量注射纳络酮可翻转盐酸吗啡的作用，（２）电刺激ＰＶＮ可抑制脊髓背角神经元伤害反应，其作用持续２０ｍｉｎ，在刺激后３ｍｉｎ作用最显著。（３）电解损毁ＰＡＧ后，刺激ＰＶＮ抑制脊髓背角神经元伤害反应仍然存在。实验结果表明：ＰＶＮ是脑内镇痛的主要核团之一，其作用通过ＰＡＧ实现，也可通过ＰＶＮ—脊髓背角直接投射的途径。Experiments were performed on rats eneathetized with 4% chloral hydrate.A pair of stimulating electrodes or stainless steel pipettes were buried in nucleus paraventricularis (PVN) or substantia grisea surrounding aqueductus mesencephali (PAG) to present stimulation,dysfunction or drug electrophoresis,while microelectrodes were used to record the response of the dorsal horn neuron of spinal cord to nociceptive stimulation of the sciatic nerve.We observed:(1)Electric stimulation of PVN or injection of morphine hydrochloride could raise the threshold of pain strikingly.Microinjection of naloxone could reverse the effect of morphine hydrochloride.(2)Electric stimulation of PVN could inhibit the response of the dorsal horn neuron to nociceptive stimulation.The effect lasted 20 minutes,the peak being at the 3 min after stimulation.(3)After damaging PAG electrolytically,the response abovementioned still existed.The results suggest that PVN is one of the major intrabraih nuclei participating in analgesia,it plays its role via PAG of its direct projection to the dorsal horn.

关 键 词：下丘脑 室旁核 止痛 脑 刺激 

分 类 号：R338.27[医药卫生—人体生理学]