3－甲酰腙一利福霉素SV及其异构体的研究  

THE STUDY OF 3-FORMHYDRAZONE-RIFAMYCIN SV AND ITS ISOMER

作　　者：王作琴 王桂芳 顾玉山 

机构地区：[1]沈阳化工研究院,东北制药总厂

出　　处：《波谱学杂志》1994年第2期187-194,共8页Chinese Journal of Magnetic Resonance

摘　　要：用发酵和化学法合成的两个３－甲酰腙—利福霉素ＳＶ样品（１￣＃，２￣＃）具有不同的物理化学性质，本文用多种ＮＭＲ技术，如￣１Ｈ，￣＿（１３）Ｃ，ＤＥＰＴ，￣１ＨＨＣＯＳＹ，反相摸式的￣１Ｈ－￣（１３）ＣＣＯＳＹ及远程￣１Ｈ－￣（１３）ＣＣＯＳＹ，并结合红外及紫外一可见光谱测试结果进行综合分析，确定样１￣＃及样２￣＃分别为酰胺式主产品及亚胺醇式导构体。根据实验结果对样１￣＃的异构化反应进行了初步的探讨．Two samples（1~#,2~#）of 3-formhydrazone-rifamycin SV produced byfermentation and chemieal modification have different physical and chemical properties。In this paper，their structures wcre determined by various kinds of NM R spcctra， suchas ~1H，^(13)C，DEPT，~1H-~1H COSY，~1H-^(13)C COSY and LR ~1H-^(13) C COSY inversemode， and by the absorption spectra of IR and UV-Vis．It was found that the twosamples were the main product of amide mode（1~# ） and　the isomer of iminol mode（2~#）． Based on the results of experiments，the isomerization of sample 1~# was discussed。

关 键 词：利福霉素 异构体 NMR 

分 类 号：R978.3[医药卫生—药品]