转输免疫脾细胞对同系成年小鼠肾综合征出血热病毒致死性感染的保护作用  

ROLE OF IMMUNE SPLEEN CELLS IN PROTECTION AGAINST FATAL HFRS VIRUS INECTION IN ADULT MICE

作　　者：卢文红[1] 姚楚铮[1] 刁保卫[1] 张满新 唐家权 罗成旺[1] 黄莉莉[1] 

机构地区：[1]中国预防医学科学院流行病学微生物学研究所

出　　处：《病毒学报》1994年第3期268-270,共3页Chinese Journal of Virology

摘　　要：转输免疫脾细胞对同系成年小鼠肾综合征出血热病毒致死性感染的保护作用卢文红，姚楚铮，刁保卫，张满新，唐家权，罗成旺，黄莉莉（中国预防医学科学院流行病学微生物学研究所，北京１０２２０６）关键词肾综合征出血热，免疫脾细胞转输，细胞免疫免疫系统在病毒感染的恢...n the previous study,we reported that cyclophosphamid immunosuppressed adult C57mice were susceptible to HFRS virus infection Using this animal model, the role of cell mediated immunity in HFRS was investigated ,Immune spleen cells taken from C57 mice immunized with HFRS virus (A 16 strain ),were transferred to syngeneic adult mice before or after intracerebral infection with A 16 virus ,to see whether the animals would be protectad from death.Intravenous transfer of 1 × 107、 4×107、 3×107、1×107and5× 106immuneSpleen cells to adult mice 2hrs before infection resulted in 100% to 50% protection Andtransfer of 1.2 ×108 and 5×107 immune spleen cells to mice 24hrs post infection ,resulted in 100%and 66.7% protection respectively .In contrast, transfer of nonimmune spleen cells offered noProtection. The survival tine of mice which received insufficient number of immune spleen cells,were longer than that of the control animals.specific viral antigen was was found in brain andlung by direct IF assay in dead mice,however,the viral antigen were scanty in the organs ofthe protected survived mice.

关 键 词：细胞免疫 肾病综合征 出血热 病毒 

分 类 号：R512.802[医药卫生—内科学]