O-甲基酪氨酸对酪氨酸抑制hCG致大鼠离体黄体细胞孕酮生成的拮抗作用  

Antagonism of O-Methyl-Tyrosine to Inhibition of HCG Induced progesterone Production by Tyrosine in Rat Corpus

作　　者：高而威[1] 程治平[2] 

机构地区：[1]北京医科大学生理教研室 [2]哈尔滨医科大学生理教研室

出　　处：《生理科学》1989年第1期28-30,共3页

摘　　要：用孕马血清促性腺激素和hCG处理未成年雌性大鼠,在hCG注射后7天取出黄体制成黄体细胞悬浮液,孵育后用放射免疫法测定孕酮含量。实验发现,酪氨酸结合的竞争性抑制剂O—甲基酪氨酸能够翻转酪氨酸抑制hCG的致孕酮生成作用,并与所用剂量有关,如果加大酪氨酸的剂量,则可克服O-甲基酪氨酸的翻转作用。由此提示,O-甲基酪氨酸是一种酪氨酸结合位点的拮抗剂,它通过阻断酪氨酸的结合来抑制酪氨酸的作用。Corpus lutea were obtained from immature rats pretreated with PMSG and hCG 7 days after hCG injection. It was found from experiments of incubation of corpus luteal cells that O-methyl-tyro-sine, a competitive inhibitor for tyrosine binding, reserved the suppresive action of tyrosine on hCG-induced progesterone secretion, depending on the dose used and the reversal effect could be overcome by increasing the dose of tyrosine. It is suggested that O-methyl-tyrosine,as an antagonist for tyrosine binding sites,might inhibit tyrosine effect through blocking tyrosine binding.

关 键 词：酪氨酸 黄体细胞 HCG 孕酮 

分 类 号：Q492.6[生物学—生理学]