P物质对5-HT引起的大鼠回肠纵行肌收缩效应的影响及其机制分析  

EFFECTS OF SUBSTANCE P ON THE CONTRACTILE RESPONSE OF LONGITUDINAL MUSCLE OF RAT ILEUM TO 5-HT

作　　者：肖强[1] 李栋生[1] 戴义隆 葛志恒 

机构地区：[1]南京医学院生理学教研室

出　　处：《生理学报》1989年第3期313-317,共5页Acta Physiologica Sinica

摘　　要：本文采用离体大鼠回肠纵行肌-肌间神经丛(LM-MP)标本,观察SP对5-HT引起的LMMP标本收缩效应的影响,并对其作用机制进行了分析。实验结果:(1) 阈下剂量的SP(5nmol/L)可明显加强5-HT(100nmol/L)引起的LM-MP收缩效应;(2) SP受体拮抗剂[D-Pro^2、DTrp^(7,9)]SP、M受体阻断剂阿托品可抑制或阻断SP对5-HT的加强效应。表明这种效应是通过SP受体中介的;(3) M受体阻断剂阿托品也可阻断SP的加强效应,而平滑肌5-HT受体阻断剂BOL对SP的加强效应似无阻断作用。这些结果提示,阈下剂量的SP对5-HT具有调制作用,并与胆碱能机制有关。The purpose of this study was to observe the effects of substance P (SP) on the contractile response of longitudinal muscle with myenteric plexus (LM-MP) of rat ileum induced by 5-HT in vitro and to analyse its mechanism. The results were as follows: (1) Subthreshod dose of SP (5 nmol/L) potentiated the 5-HTinduced contractile response; (2) Both [D-Pro^2 D-Trp^(7,9)]-SP and atropine inhibited or blocked this potentiated effect suggesting that the effect was mediated by SP receptors; (3) This effect was not blocked by bromolysergic acid diethylamide (BOL) The results suggest that SP of subthreshold dose might modulate the effect of 5-HT, and a cholinergic mechanism might be involved in the modulation.

关 键 词：P物质 血清素 纵行肌收缩 

分 类 号：R337.2[医药卫生—人体生理学]