强啡肽和心钠素可能参与可乐定的降压利尿作用  

DYNORPHIN AND ATRIOPEPTIN MAY BE INVOLVED IN THE DEPRESSOR MECHANISM OF CLONIDINE

作　　者：尹丽艳[1] 高晓明[1] 谢翠微[1] 汤健[1] 

机构地区：[1]北京医科大学心肺内分泌研究室

出　　处：《生理学报》1989年第3期249-254,共6页Acta Physiologica Sinica

摘　　要：静脉注射可乐定引起大鼠血压降低和心率减慢。此效应可被α受体阻断剂酚妥拉明所对抗。预先腹腔注射大剂量阿片受体阻断剂纳洛酮或静脉注射强啡肽抗体可以部分阻断可乐定的降压效应。静脉注射可乐定可以引起大鼠尿量显著增加,该效应也可被大剂量的纳洛酮所阻断。静脉注射可乐定引起明显的心钠素释放,这一作用可被α受体阻断剂所完全对抗,亦可被阿片受体阻断剂所部分阻断。以上结果说明强啡肽与心钠素可能参与可乐定的降压利尿作用。Intravenous injection (iv) of clonidine significantly induced depressor and bradycardiac responses in rats. These responses were found to be blocked by iv α-adrenoreceptor blocker phentolamine, intraperitoneous injection (ip) of naloxone (10mg/kg) or iv antidynorphin-IgG(80μl). Furthermore, clonidine (iv) induced a significant increase of urine volume, which was also partly blocked by naloxone (10mg/kg). A dramatic increase of rat plasma immunoreactive atriopeptin induced by clonidine(iv)was partly antagonised by pretreatment with naloxone (4mg/kg) or phentolamine (10mg/kg). These results show that dynorphin and atriopeptin may be involved in the depressor mechanism of clonidine.

关 键 词：强啡肽 心钠素 降压利尿 可乐定 

分 类 号：R331.36[医药卫生—人体生理学]