酒精中毒大鼠肝细胞的体视学研究  

STEREOLOGICAL STUDY ON HEPATOCYTES OF ALCOHOLISM RATS

作　　者：郑淑芳[1] 张乃鑫[1] 章明放[1] 王晓燕[1] 

机构地区：[1]天津医学院

出　　处：《承德医学院学报》1994年第4期270-273,共4页Journal of Chengde Medical University

摘　　要：１０月龄雌性ＳＤ大鼠１３只，７只自由饮用２０％酒精溶液１３周（实验组）；６只自由饮用去离子水１３周（对照组）。用体视学的计量方法计量两组大鼠肝细胞核的体密度（Ｖｖｎ）、面密度（Ｓｖｎ）、比表面（Ｑｎ）、肝细胞的核质比（Ｖｎｐ）、肝细胞的平均直径（ＤＨ）。结果表明，实验组大鼠肝细胞核的体密度（Ｖｖｎ）、面密度（Ｓｖｎ）、核质比（Ｖｎｐ）均显著增高；肝细胞核的比表面（Ｑｎ）、肝细胞的平均直径（ＤＨ）两组间无差异。提示，酒精会引起大鼠肝细胞的显著增生。Thirteen female SD rats of ten-old were used to study the affect ofalcoholism on hepatocytes by stereological method. Among them, 7 rats drinking freely20%ethanol for 13 weeks were treated as experimental group and 6 rats drinking freely deionic water for 13 weeks as control group. Using the stereological method, the stereological parameters of the hepatocytic nuclei were measured , such as volume density (Vvn) , surface density (Svn) , specific surface(Qn) , nuclei-cytoplasic ratio(Vnp) ,and mean diameter of the hepatocytes(DH). The Vvn , Svn, and Vnp in theexperimental group were significantly increased but there were no statistic difference inQn and DH between the two groups. The results suggest that ethanol can induceobvious proliferation of hepatocytes.

关 键 词：酒精中毒 肝细胞 体视学 

分 类 号：R595.602[医药卫生—内科学]