欧芹素乙和异欧芹素乙对小鼠腹腔巨噬细胞体外释放肿瘤坏死因子的抑制作用  

Inhibitory Effects of Imperatorin and Iso-imperatorin on Tumor Necrosis Factor Release from Mouse Peritoneal Macrophages

作　　者：嵇扬[1] 曾国钱[1] 芮耀诚[1] 

机构地区：[1]第二军医大学药学院药理学教研室,解放军202医院药剂科

出　　处：《第二军医大学学报》1994年第6期511-513,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金

摘　　要：研究了欧芹素乙（Ｉｍｐｅｒａｔｏｒｉｎ，Ｉｍｐ）和异欧芹素乙（Ｉｓｏ－ｉｍｐｅｒａｔｏｒｉｎ，Ｉｓｉ）及对照药物维拉帕米（Ｖｅｒａｐａｍｉｌ，Ｖｅｒ）对小鼠腹腔巨噬细胞体外释放肿瘤坏死因子（Ｔｕｍｏｒｎｅｃｒｏｓｉｓｆａｃｔｏｒ，ＴＮＦ）的影响。结果表明：Ｉｍｐ、Ｉｓｉ及Ｖｅｒ对小鼠腹腔巨噬细胞体外释放ＴＮＦ具有显著的抑制作用。药物浓度在１０－６～１０－４ｍｏｌ／Ｌ范围内，该抑制作用呈剂量依赖性：药物浓度达１０－４ｍｏｌ／Ｌ时，则可完全抑制ＴＮＦ的释放。The effects of imperatorin (Imp) and iso-imperatorin(Isi) on tumor necrosis factor (TNF) release from mouse peritoneal macrophages were investigated. It was found that Imp and lsi significantly inhibited TNF release from mouse peritoneal macrophages. At the concentration of 10-6～10-4 mol·L-1, the inhibitory effects were presented by Imp and Isi in a dose dependent manner. At 10-4 mol/L TNF release was entirely inhibited by each drug.

关 键 词：肿瘤坏死因子 巨噬细胞 欧芹素乙 异欧芹素乙 

分 类 号：R285.5[医药卫生—中药学] R963[医药卫生—中医学]