职业性铅接触者红细胞游离原卟啉(FEP)生物效应的研究  

Study on biological effects of free erythrocyte-protoporphyrin in lead-operating workers

作　　者：王贤[1] 刘立波[1] 李玲[1] 顾雷[1] 

机构地区：[1]白求恩医科大学环医系劳动卫生教研室

出　　处：《白求恩医科大学学报》1989年第2期140-142,共3页Journal of Norman Bethune University of Medical Science

摘　　要：铅能抑制卟啉代谢中的某些酶,使其代谢产物如尿ALA,尿粪卟啉(CPU)、FEP等在尿中或血中含量增高。本文对155名铅作业工人做了调查。结果表明,铅接触浓度在均值等于0.036mg/m^3时(铅烟最高允许浓度为0.03mg/m^3),FEP值和对照组比较已有显著差异。FEP和尿ALA,尿铅相关性较好,且较敏感,可作为评价铅早期毒性的重要指标之一。正常人上限定为50μg/dL为宜,建议推广使用。Lead is capable of restraining some enzymes in porphyrin metabolism and causing an increase of its metabolites in urine or blood, such as urinary δ-aminolevulic acid (ALA-U) , urinary corporphyrin (CP-U) , FEP, etc. One hundred and fifty-five lead-operating workers were investigated, and it was shown that there was a great difference in FEP between the exposure and control groups when the average lead concentration in atmosphere was 0.036mg/m3 (the maximal allowable concentration of lead fume is 0.03mg/ m3) . FEP and ALA or FEP and Pb-U were closely correlated. Thus, FEP may be used as one of the important indexes in evaluating lead intoxication in early stages, and it is worthwhile to be widely popularized. The upper limit for common people is 50μg/dl.

关 键 词：铅中毒 卟啉 红细胞 生物效应 

分 类 号：R135.11[医药卫生—劳动卫生]