二甲苯胺噻唑对绵羊血液及脑脊液中去甲肾上腺素的影响  

EFFECT OF XYLAZOLE ON NOREPINEPHRINE CONCENTRATIONS IN CEREBROSPINAL FLUID AND BLOOD IN SHEEP

作　　者：刘秀华[1] 李涛[1] 乔桂林[1] 马莺[1] 

机构地区：[1]东北农业大学

出　　处：《东北农业大学学报》1994年第2期141-143,共3页Journal of Northeast Agricultural University

摘　　要：试验用ＨＰＬＣ法研究了二甲苯胺噻唑（静松灵）对神经递质去甲肾上腺素（ＮＥ）的影响．绵羊肌注２．５ｎｇ／ｋｇ静松灵后，脑脊液及血液中ＮＥ含量呈持续性减少，３小时降到最低．血液中０时ＮＥ浓度３．６９９±０．３８１ｎｇ／ｍＬ，３小时ＮＥ含量０．５５９±０．１１７ｎｇ／ｍＬ（±ＳＥ，ｎ＝５，Ｐ＜０．０１），下降了８３．８％；脑脊液中ＮＥ浓度０时３１．３２±４．８８ｎｇ／ｍＬ，３时６．２６±２．００ｎｇ／ｍＬ（±ＳＥ，ｎ＝４，Ｐ＜０．０１），下降了８０％。血液与脑脊液中ＮＥ浓度变化呈正相关ｒ＝０．９３１．这两种体液中ＮＥ含量变化揭示了静松灵对中枢交感神经系统有抑制作用，静松灵的镇静、镇痛、中枢抑制作用与递质ＮＥ有密切关系．The effect of xylazole on norepinephrine(NE)was studied with HPLC.There is a sustained decrease in NE levels of both the cerebrospinal fluid(CSF) and the blood as compared with the levels of the controls after i. m.administration of xylazole(2.5mg/kg).The lowest concentration of NE appeared at 3 hours' time,blood NE level fell by 83.78% from 3.699 ±0.381 ng/ mL to 0.559± 0.1 17ng / mL (±SE,n= 5, P< 0.01);CSF NE level fell by 80%from 31.32 ± 4.88ng/mL to 6.26 ±2.00ng/mL(± SE, n = 4, P<0.01).Positive correlation between CSF and blood NE levels was observed. r = 0.93. Varieties of NE levels in CSF and blood suggest that sedative, analgesic and depression actions of xylazole have close relation to transmitter NE.

关 键 词：二甲苯胺噻唑 绵羊 去甲肾上腺素 

分 类 号：S859.791[农业科学—临床兽医学]