大鼠海马CA1区神经元在衰老过程中的形态学变化  

MORPHOLOGICAL CHANGES OF NEURONS OF SECTOR CA1 HIPPOCAMPUS OF RATS DURING AGING

作　　者：张兵[1] 侯家骥[1] 

机构地区：[1]兰州医学院组织胚胎学教研室,730000

出　　处：《动物学报》1994年第4期412-418,共7页ACTA ZOOLOGICA SINICA

摘　　要：对不同年龄组雄性ＳＤ大鼠海马ＣＡ１区锥体层神经元分别做光学和电镜观察与测定，结果表明ＣＡ１区锥体层单位面积内神经元数目随增龄下降达３３％（Ｐ＜０． ００１），同时伴有锥体层厚度的增加（Ｐ＜０. ００１）；ＣＡ１区部分锥体神经元细胞器与胞突在老化过程中出现一系列形态学变化。本文对上述结果及其意义进行了讨论。The neurons sector CA1 in hippocampus of young (3 months), adult (12 months), and aged (27 months) SD rats were observed under light and electron microscope. The light microscopic results indicated that the density of neurons in stratum pyramidale of sector CA1 decreased (33%, P＜0.001) while the thickness of stratum pyramidale increased with aging (P<0. 001 ). Some pyramidal neurons in stratum pyramidale of sector CA1 showed a series of morphological changes with aging under electron microscope. These changes and their significance were discussed.

关 键 词：海马 锥体神经元 衰老 形态学 

分 类 号：R338.26[医药卫生—人体生理学] R324[医药卫生—基础医学]