二阶导数差示脉冲极谱法用于醋酸氟氢可的松的定量研究  

Studies on Quantitative Determination of Fluorohydrocortisone Acetate by Secondary Derivative Differential Pulse Polargraphy

作　　者：梁云爱[1] 孙吉令[1] 罗振[1] 孙金辉[1] 

机构地区：[1]日照市药品检验所,山东省药品检验所,山东医科大学,中科院大气物理研究所

出　　处：《分析测试学报》1994年第4期63-66,共4页Journal of Instrumental Analysis

摘　　要：用二阶导数差示脉冲极谱法对醋酸氟氢可的松进行了定量分析。在０．００１ｍｏｌ／Ｌ硫酸＋乙醇＋水（１＋２５＋２４）的底液中，醋酸氟氢可的松于－０．３４０Ｖ（ｖｓＡｇ／ＡｇＣｌ）处出现一良好的二阶导数差示脉冲极谱峰，在５～１４０μｇ／ｍＬ范围内，醋酸氟氢可的松的浓度与其二阶导数差示脉冲极谱峰幅值呈线性关系，检测限为０．４ｎｇ／ｍＬ。本法操作简便、快速、灵敏、结果准确。A method was developed for the determination of the fluorohydrocortisone acetate by the secondary derivative differential pulse polarography(SDDPP ).By using solution containing 0.001mol/L sulfuric acid+ethanol+water(1+25+24),there was a very good SDDPP peak at-0.34V(vs Ag/Agcl).The linear range was 5～140 μg/mL,The determination limit is 9.6×10￣(-10)mol/L.This method is simple,rapid and sensitve.The result is accurate.

关 键 词：脉冲极谱法 醋酸 氟氢可的松 

分 类 号：R977.11[医药卫生—药品]